《北上广不相信眼泪》除了剧情吸睛抓人外，凭借本剧复工的马伊琍在片花里的表现也十分抢眼。剧中马伊琍饰演的白领丽人潘芸，既要协助丈夫隐婚上位，又要抵挡住来自上司魅力熟男于德伟(张兆辉饰)的追求，还要对抗青春靓丽的情敌梁伊(刘美含饰)，可谓时刻满血，堪称最强女人。
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